New York Times transcript of 2001 Sotomayor speech, here, where she says physiological differences may and will make a difference in the administration of justice and make decisions better:
Whether born from experience or inherent physiological or cultural differences, a possibility I abhor less or discount less than my colleague Judge Cedarbaum, our gender and national origins may and will make a difference in our judging. Justice O'Connor has often been cited as saying that a wise old man and wise old woman will reach the same conclusion in deciding cases. I am not so sure Justice O'Connor is the author of that line since Professor Resnik attributes that line to Supreme Court Justice Coyle. I am also not so sure that I agree with the statement. First, as Professor Martha Minnow has noted, there can never be a universal definition of wise. Second, I would hope that a wise Latina woman with the richness of her experiences would more often than not reach a better conclusion than a white male who hasn't lived that life.
Senate Republicans Alexander, Bond, Collins, Grahamnesty, GreggTARP, Lugar, Martinez, Snowe and Voinovich voted to confirm her, 68-31.